fastest banhammer in the west (6 minutes)
i should be writing
fastest banhammer in the west (6 minutes)
90% of LLM training quits just before achieving sentience
she was stealing from cryptobros which is pretty funny and morally neutral, because cryptobros don’t deserve having money
on top of these 11 billion dollars recovered, meaning that these were stolen, she also lived rent free in whatever bahamas mansion was bought with sbf’s money, with all their ranked competitive polycule roommates
it’s 100% cooperation with the court that cut down sentence that hard
but she also spilled beans on SBF, that’s why she’s got only 2 years and not 25 like SBF despite being equally deep in the fraud
In terms of vapor pressure, ammonia behaves a lot like propane. You can store it pretty much like propane, liquified under pressure, but it has less energy density and high heat of evaporation so it’s best to withdraw it as liquid to not freeze out container
was/is he unusually shitty or notorious for something
Bootleg mining was a thing in coal-bearing areas of Poland and Ukraine during times of greatest economic shitshows (early interbellum and 90s)
That means that DHL driver has to take bike instead of car for this one
yeah so it seems
a twitter thread by sv ceo where comment section wants to do some recreational union busting, political assassinations and automating away longshoremen (lmao) over checks notes black friday bringing slightly less profit to mass retailers. to which i say, fuck your black friday then
and he says that it’ll affect elections? specifically in “don’t do anything visible in interest of unions or trump will win” kinda way? what kinda madhouse is this americans explain https://xcancel.com/typesfast/status/1836498432510562788#m
1 post 6 comments joined 3 months ago, “i’m naive to crypto” “I want to host an instance that serves as a competitive alternative to Facebook/Threads/X to the users in my country,”
yeah he doesn’t even have to charge for interacting with him i’ll avoid him without it
that’s lemm.ee last time i’ve checked. he made that mistake 14x
1911 fans are people who just won’t give up their beeg gun for something smaller that still makes sense, then refuse to train properly and expect badly placed shot to be good enough bc mah stopping powah. stubborn, outdated and propping their claims with horseshit, this fits musk perfectly. (this includes us army that refused to switch to intermediate calibre rifle until it fucked them over in vietnam but i digress)
if you want a deep dive, show me a procedure this thing is supposed to be using because i found nothing serious
also just noticed that their warrant canary does not include proof of date like news snippet and is not signed
a sort of problem that only lw forums users have
technical aspect seems to be for now that israeli secret services intercepted and sabotaged thousands of pagers to be distributed for hezbollah operatives, then blew them up all at once. it does look like small, reportedly less than 20g each explosive charge, but orange site accepted truth is that it was haxxorz blowing up lithium batteries. israelis already did exactly this thing but with phone in targeted assassination, and actual volume of such bomb would be tiny (about 10ml)
right, so let’s start with equipment. instead of using lab-scale techniques with lab-scale equipment, they instead decided to make an industrial-type reactor but tiny. so for a thing that stirs and heats your reaction mix they came up with arduino-powered jars that cost all in all $300-500. you know what does this job? a hotplate-magnetic stirrer combo with external thermometer that you can get on amazon for $70ish, with some associated glassware that still will be cheaper than $300 total, won’t leach plasticizers and that you can actually clean up thoroughly. if you’re looking for case of coder mindset where every problem can be solved with iot and 3dprinting, it’s there. that thing only really allows purification by extraction and crystallization, but this is straight up not enough for some cases. maybe they’re limiting their syntheses to cases where it is enough. sometimes you need to run distillation, if it’s something other than solvent this means vacuum pump ($2k ballpark) with dry ice trap (that has to be fused quartz and not normal glass) and dry ice. sometimes you need to run chromatographic column, that alone is easy if you know what you’re doing but it requires a lot of solvent that would be ideally recycled because there’s a lot of solvent involved (100x mass of compound to be purified is on lower end) (honeywell doesn’t want you to know this but recycled solvent is free you can do it in-house. i recycled 1500L). then you need equipment to evaporate that solvent (rotovap) and recycle it. like derek lowe said, it’s a lot of like trying to make your own aluminum foil
and then there’s entire waste management of it all, and there will be a lot of waste that you just can’t flush down the drain
another problem is that they expect anyone to be tied to this rube goldberg model reactor and don’t provide instructions in human readable form, but only as instructions for that contraption, and even that only through chatbot (??) if you can pull something let me know. (they have something better than machine generated free association right? as in, something they have tested. i don’t expect orgsyn.org level work where they repeat all procedures they publish, but at least something grounded in reality)
like you said there’s zero quality control and options for purification are extremely limited, this alone will get people killed. some of their testing was outsourced, and there are some ancient methods of determining what you’ve got based on things like melting point, but this is critically sensitive to fucking up due to not knowing what you’re doing. but this won’t tell you what it is, it only allows you to compare your result to someone’s else result to check if they match. i don’t know how likely in this case would be that fucking up synthesis will get patient killed, but in their previous one where they tried to cook naloxone there was a way to fuck up synthesis that would give compound with opposite activity to what was intended (oxymorphone).
regarding sofosbuvir. it’s fluorinated, which means they either
e: by now i suspect they just ran with outputs from 2 without actually trying to make in their jarware. there’s also stereogenic centre on phosphorus which can, but doesn’t have to, make things significantly harder, but idk how actually important this is
and this is all forgetting about that sofosbuvir is used in combination therapy, where all the other drugs come from
the other drugs are also patented and just from looking at them it seems to me that these require a bit more specialized starting materials and a few steps that involve palladium couplings
synthesis-prediction software is an alleged thing that will sometimes work, i personally never did, but if you do use it, it’s critically important to know what you just have cooked because these outputs are predictions, not procedures. in this case point is moot because they just can replicate what is in patents, as patents describe something that already works, even if some details are missing
there are degrees to it. their abortion cards from what i understand just repurpose veterinarian misoprostol, which has similar if not the same requirements for purity and such and because it’s also used in humans, i won’t be surprised if it (as in, API) rolls off the same production line. but here, they don’t cook anything so there’s less room to fuck up. this is also not golden standard on how pharmaceutical abortion can be done now, but it’s available and it’s basically unregulated which i suspect was the entire point
single sane take from hn that is grayed out for some reason. something like quarter of discussion involves nootropics
This looks more like a libertarian nightmare than an anarchist dream. I couldn’t care less what you inject your body with, and will always support open science, but this is no solution to the USA’s disastrous healthcare system.
The real “right to repair your body” necessarily involves a socialized healthcare system, like in the rest of the West.
e: looked up their synthesis planner. for the easy example they mentioned (ivacaftor) 1/3 of the last step reactions are wrong, and these that aren’t require mildly to wildly spicy reagents (allergens, toxic or corrosive, that last bit is expected). first few candidates split entire molecule in two parts across amide bond (correctly) into amine and acid. acid is listed at $1/g amine is listed at $28/g, which are prices cited in 404media article actual link provided lists amine at $28 per 10mg. predicted synthesis of amine does not include the actual pathway that i found on reaxys (and one that would work in garage). ivacaftor is listed as commercially available at $86/g, but link provided only lists 10mg at $12. i take they just punched these compounds into their wrong prediction machine and ran with numbers it provided without checking
that’s not even synthesis planner like i’ve seen before that will provide you with suggested reaction conditions, any extra reagents and all that jazz, that still require careful supervision and good analysis of reaction mixture afterwards. no, here you have two bits that you can possibly stitch up to get something, fuck you, you won’t get anything better. figure out all the other bits, draw the rest of the fucking owl on your own
even if it was quenched the right way: downtime, helium, restarting the entire thing would also cost pretty penny, and maybe replacement of damaged magnet too if that’s what they did