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Joined 9 months ago
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Cake day: September 28th, 2023

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  • Well that’s good, but even if we are generous and say half the ~80 million gun owners in the US, are as responsible with their weapons as you are; that leaves a fuckton of gun wielders who are not responsible.
    I am not outright anti-gun, but it makes no sense to me it took two tests and several weeks of waiting, to get a driver’s license; and if I want to do e.g. more than basic electrical or plumbing changes in my home, I should get a permit and there will be an inspection. Yet I could waltz into a store, buy guns like I was a personal army, and at worst I would have to wait a couple days to pick them up. As far as I know, there are 0 requirements or inspections for if you have a gun safe; let alone any form of test or licensing of if you are just barely competent and safe weilding them.








  • Meanwhile:

    Sinclair, Inc., doing business as Sinclair Broadcast Group, is a publicly traded American telecommunications conglomerate that is controlled by the descendants of company founder Julian Sinclair Smith.
    Headquartered in the Baltimore suburb of Cockeysville, Maryland,[3] the company is the second-largest television station operator in the United States by number of stations (after Nexstar Media Group), owning or operating a total of 193 stations across the country in over 100 markets (covering 40% of American households) and is the largest owner of stations affiliated with Fox, NBC, CBS, ABC, MyNetworkTV, and The CW.

    A 2019 study in the American Political Science Review found that “stations bought by Sinclair reduce coverage of local politics, increase national coverage and move the ideological tone of coverage in a conservative direction relative to other stations operating in the same market.”[5][6]
    The company has been criticized by journalists and media analysts for requiring its stations to broadcast packaged video segments and its news anchors to read prepared scripts that contain pro-Trump editorial content, including warnings about purported “fake news” in mainstream media, while Trump has tweeted support for watching Sinclair over CNN and NBC. Wikipedia









  • Very interesting research!

    SUMMARY

    Cigarette smoking is a well-known risk factor inducing the development and progression of various diseases. Nicotine (NIC) is the major constituent of cigarette smoke. However, knowledge of the mechanism underlying the NIC-regulated stem cell functions is limited. In this study, we demonstrate that NIC increases the abundance and proliferative activity of intestinal stem cells (ISCs) in vivo and ex vivo. Moreover, NIC induces Yes-associated protein (YAP)/Transcriptional coactivator with PDZ-binding motif (TAZ) and Notch signaling in ISCs via α7-nicotinic acetylcholine receptor (nAchR) and protein kinase C (PKC) activation; this effect was not detected in Paneth cells. The inhibition of Notch signaling by dibenzazepine (DBZ) nullified the effects of NIC on ISCs. NIC enhances in vivo tumor formation from ISCs after loss of the tumor suppressor gene Apc, DBZ inhibited NIC-induced tumor growth. Hence, this study identifies a NIC-triggered pathway regulating the stemness and tumorigenicity of ISCs and suggests the use of DBZ as a potential therapeutic strategy for treating intestinal tumors.

    https://www.biorxiv.org/content/10.1101/2024.01.02.573853v1