late to the party. Q: What is it that corporations will not tolerate about online commmunity, crowdsourced news and info?? Digg, Delicious, Slashdot, Reddit… all eaten and changed?

Silly thoughts…

• the life in a discussion site is the exchange of ideas/thoughts. For that to happen users need to actually listen, process, and discuss. Reddit’s structure has discouraged that for years.

• signal to noise ratio - in order for the discussion board site to be useful, there’s some magic signal to noise ratio that has to be maintained. Otherwise, its some style of chaos.

• Why I left - in a technical subreddit, someone asked a technical question ‘Who still uses XYZ, and why?, I never quite understood it’, I gave a short primer on how it worked, with a couple analogies. The OP replied testily ’ I don’t need anyone to explain to me how it works.'. And then testily to other helpful responses, and then deleted their acct.

• The experts left most of the technical subs I am in 5-10 years ago. My guess is that discussions are mostly noise: things I could have learned if I read the instructions, or how can I do this without understanding anything about it.

• somewhere I read that the upvote/downvote counts on the front page are made up… modified by reddit… so that people don’t know what they need to do to get to the front. By adding this, they gave themselves full editorial control of the front page. It’s downhill from there.

Win7 and Win10.

: -)

we can disagree about much greater things. humans have and have figured it out.

we can disagree about eating animals. for me it may be a sacrilege and for my neighbor it may be lunch. I am under no obligation to agree with her, nor is she under any obligation to agree with me.

She can think I am insane for protecting a dumb animal.

I can think she is insane for destroying life.

She can offend my morality. And I hers. This is disagreement. We do not have to agree, and we have every right to our understanding of the universe.

I will avoid mentioning other real-er areas because it gets people all in a tizzy and makes this kind of discussion take far too long. but if we extrapolate just a bit, disagreeing with another person, even about deeply held beliefs is part of what we do in civilization.

in the quiet, the real quiet of it all, after the yelling and flaming on the internet, we have two types of thought. One that thinks that people have both the ability and the freedom to say what they think, out loud, and even to entire groups of people. And we have a group of people that thinks we are all safer and happier if we don’t let them. That group also thinks we have to agree (with them), they say one word a lot, ‘tolerance’ but curiously they mean that in one direction: the direction they identify with. In the same way, they falsely equate :“disagreeing with me” to “hating me”.

… its … not ok… to … tell… jokes… about… certain… people ?

why don’t they ever add the “… in this survey” part at the end?

Thanks for saying this. It's features at price point.

"It's better than the Pi at only 3x the price."

And what's with the "Avoid the Raspberry PI" sentiment? They are hard to get (?). I've been using the Pi for forever, and have zero 'product' complaints that would make me want to "Avoid the Pi'. If anything, I have plans for more. Again, the price - A Zero2W is $15 MSRP. For $15, You can put that in everything. A Pi4 is $35. Its just a great deal.

"In conclusion, we used a strategy for upregulating mitophagy by Usp30 deletion, with similar results obtained with a pharmacological USP30 inhibitor. These strategies to reduce USP30 lead to enhanced mitophagy and potent protection against αSyn toxicity. This work validates inhibition of USP30 as a promising strategy for further testing for potential disease-modifying effects in PD."

Mitophagy - clearing out old stuff from cells. Clears out dysfunctional mitochondria from cells.

aSyn toxicity - alpha synuclein - a protein found in the body, esp. in the brain. [We think it helps with some neruo-regulation, and DNA repair. We think these two go together. ] In people with diseases like Alzheimers an Parkinsons there appears a 'buildup' of αlpha-synuclein in places and a corresponding degeneration of other areas.

This study tried to crank up the clearing out of old mitochondria in Mice first by modifying their genes to removing (knocking out) the ability to make USP30 (an enzyme). They also cooked up a molecule that could just block USP30 (it gets there first and sits in the way).

Both methods worked to protect mice when they tried to give them alpha synuclein problems. Of course there's lots of other questions about what else is affected, but this has potential to be fix this one part of the problem.

Do we allow people to choose how they indoctrinate their children? We all are. We all were. The only question is who's indoctrination.

Hmmmmm. Opensecrets says Harlan Crow has donated: 14,700,000.00 to Polical canditates and parties over 30 years.

In 2022 Crow gave $184,400 to the National Rep. Congr. Comittee, and $750,000 The Congressional Leadership Fund ( a Rep. pac), and $150,000 to 'take back the house 2022', and $725,000 to Mitch McConnels pac, and $175,000 to the Rep. Party of Texas, and $96,000 to other Dem. candidates/groups.

2 Questions…

He donated how much to this guy?

and why is it news?