It’s only depressing if you’ve convinced yourself that you’re something more than an intelligent ape.
If you think about it from the perspective of an animal that had no concept of time, space, ethics, or philosophy just a few hundred thousand years ago, then we’re actually pretty impressive.
We probably won’t have any significant effect on the galaxy, but we sure have an effect on Earth.
This is a weird one, but Astepro nasal spray for allergies. The name brand is a little unpleasant to blast up my nose because of the smell/taste. But the off brand stuff is absolutely foul and bitter. I would get random whifs and drips of the nastiness in the back of my throat for an hour.