Only thing you might need to change is the configuration for which port the pi-hole web server (UI) will be running on. Because octoprint already uses Port 80 by default, you might have to assign another port for the pi-hole service. (I believe it also defaults to 80. That would crash because it can't bind to the same port). That should be a pretty simple config change though.
I had it setup using docker at the time. Both pihole and octoprint as individual containers…
But I assume you should be able to just install and run the package locally on the octopi distro.
Only thing you might need to change is the configuration for which port the pi-hole web server (UI) will be running on. Because octoprint already uses Port 80 by default, you might have to assign another port for the pi-hole service. (I believe it also defaults to 80. That would crash because it can't bind to the same port). That should be a pretty simple config change though.
Just did a quick Google… There are some resources and tutorials online of people doing exactly that. Take a look!
https://www.google.com/search?q=setup pihole on octopi
Thanks, guys! I'll set this up soon.