Well, of course. NoScript blocks all JS by default other than the capabilities allowed in the "default" mode. uBlock Origin allows all JS by default, but it can be made to act like NoScript in that it too will block JS by default.

I have manually worked out which domains need to be allowed (uBlock + NoScript) and which capabilities to allow from each domain (NoScript, I do not see how one can do this in uBlock) in sites that I visit a lot (lemmy, old.reddit, youtube, piped, github etc). For the rest of the internet, my JS is turned off (surprisingly, most things work for my usage, but I just read blogs/text-based content for the most part when I'm surfing the internet). YMMV